Key Points
- Red flags indicate possible structural brain or cervical spine injury requiring emergency department referral
- Key red flags: prolonged or deteriorating consciousness, seizures, repeated vomiting, worsening headache, pupillary asymmetry, focal neurological deficits, severe neck pain
- Higher-risk populations (age ≥65, anticoagulant use) have a lower threshold for concern, particularly for intracranial bleeding
- Any person who is not lucid or fully conscious should be assumed to have a more severe TBI or cervical spine injury until proven otherwise
Red Flags Requiring Emergency Referral
The following warrant immediate emergency department assessment, as they may indicate structural brain injury (e.g. intracranial bleeding) or cervical spine injury:
Consciousness and Cognition
- Prolonged loss of consciousness (≥2 minutes), or any deterioration in conscious state
- Inability to recognise people or places
- Increasing confusion, restlessness, agitation, or combativeness
- Excessive drowsiness or inability to be woken
Neurological
- Seizures or convulsions
- Pupillary asymmetry (one pupil larger than the other)
- Dysarthria (slurred speech)
- Weakness, tingling, or numbness in arms or legs
- Ongoing diplopia or other significant visual disturbances
Other Physical Signs
- Severe or worsening headache
- Repeated vomiting (>1 episode in adults; any vomiting in children)
- Severe neck pain or midline cervical tenderness
- Ongoing severe dizziness/vertigo
- Significantly unusual or inappropriate behaviour / personality changes
Higher-Risk Groups
The comparative significance of these red flags is heightened in:
- People aged ≥65 years (elevated risk of intracranial bleeding)
- Patients on anticoagulants or antiplatelets
- Prolonged post-traumatic amnesia (>12 hours)
Additional Notes
- Symptoms can appear or worsen in the first 24 to 48 hours after injury, so ongoing monitoring is essential
- Clinical decision rules (e.g. Canadian CT Head Rule) can help guide imaging decisions in the ED
See sources cited
- An overview of concussion/mild traumatic brain injury management ...
- Concussion – Parachute
- [PDF] Concussion Signs And Symptoms Checklist - CDC
- [PDF] VA/DoD Concussion-Mild Traumatic Brain Injury Clinical Practice ...
- Concussion Management in the Emergency Department | Sports Medicine Section
- Current Concepts in Concussion: Initial Evaluation and Management
Evidence Validator
Heidi Clinical Team4 Contributions
Dr. Sasha Sadiq
Primary Care / Emergency Medicine•AU

