Genomic Test Requisition Review Note

**Genomic Test Requisition Review Note** **Date of Review:** 1 November 2024 - Full Review **Submitting Provider and Institution:** Dr. Emily Carter, MD, PhD, Genetics Department, St. Mary's Hospital, Contact: emily.carter@stmaryshospital.org, Referring Genetic Counselor: Jane Doe, MS, CGC **Test Requested:** Whole Exome Sequencing, Version 3.2, Laboratory Accession Number: WES-2024-00123, Clinical Assay **Clinical Indication:** Patient presents with developmental delay, hypotonia, and dysmorphic features. Suspected autosomal dominant inheritance. HPO terms: HP:0001263, HP:0001250. Urgent testing requested due to prenatal timeline. **Specimen Details:** Blood sample, arrived in good condition, collected on 28 October 2024, shipped within 24 hours, sample volume: 5ml, DNA yield: 50 ng/µl, chain of custody maintained. **Preliminary Assessment:** Requisition is complete and valid. Test choice aligns with clinical indication. All necessary documents, including consent forms and clinical summaries, are attached. Insurance preauthorization confirmed. Case meets institutional test eligibility guidelines. **Test Approval and Processing Status:** Test approved and batched for high-priority queue. Internal workflow code: HPQ-2024-EXOME **Initial Observations or Concerns:** No early red flags identified. Phenotype aligns with requested test. No prior testing duplication noted. Consent forms are correctly matched. No pre-analytical errors suspected.